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Allele Frequency Calculator

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Allele Frequency Calculator
In population genetics, allele frequency is used to reflect the genetic diversity of a population species. It is also referred to as gene frequency. It is a measure of relative frequency of a gene on a genetic locus in a population. The frequency is expressed in terms of percentage. Hardy-Weinberg Equation can be used to find the frequency of the gene / allele. Use this online calculator to estimate the relative frequency of a variant of a gene in a specific population using Hardy-Weinberg Equation.

Gene Frequency Calculation using Hardy-Weinberg Equation

Formula:

pfreq = (CH + (0.5 * H)) / (CH + H + RH)
qfreq = (RH + (0.5 * H)) / (CH + H + RH)

Where,
pfreq = p Allele Frequency
qfreq = q Allele Frequency
CH = Common Homozygotes
H = Heterozygotes
RH = Rare Homozygotes
Example
If the common and rare homozygotes are 12 and 3 and heterozygotes is 10, then the gene frequency based on the Hardy-Weinberg Equation can be calculated as
pfreq = (12 + (0.5 * 10)) / (12 + 10 + 3)
pfreq = 17 / 25
pfreq = 0.68

qfreq = (3 + (0.5 * 10)) / (12 + 10 + 3)
qfreq = 8 / 25
qfreq = 0.32

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